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Difficulty swallowing and abnormal heart rhythms. Non-muscle symptoms may also include learning difficulties, daytime sleepiness, infertility and early cataracts. Those with myotonic MD have a decreased life expectancy. Limb-girdle muscular dystrophies are inherited disorders, which first affect the muscles around the shoulder girdle and hips. This appears in the teens to early adulthood and affects males and females. LGMDis caused by a mutation in any of at least 15 different genes that affect proteins necessary for muscle function. In most cases, both parents must pass on the non-working defective gene for a child to have the disease autosomal recessive disorder. However in some rare types only one parent needs to pass on the bad gene to affect the child autosomal dominant disorder. In its most common form, Limb-girdle muscular dystrophy causes progressive weakness that begins in the hips and moves to the shoulders, arms, and legs. Within 20 years, walking becomes difficult or impossible. Sufferers typically live to middle age to late adulthood. Heart muscle weakness and abnormal electrical activity of the heart can increase the risk of palpitations, fainting, and sudden death. Most patients with this group of diseases live into adulthood, but do not reach their full life expectancy. Facio-scapulo-humoral muscular dystrophy FSHD: Facio-scapulo-humeral muscular dystrophy FSHD is a genetic muscle disorder in which the muscles of the face, shoulder blades and upper arms are among the most affected. This form of muscular dystrophy appears in the teens to early adulthood and affects males and females. It is a genetic disorder. The weakness can be severe enough to interfere with walking. Hearing loss and abnormal heart rhythms may occur, but are rare. Disability is often minor. Lifespan is usually not affected. Congenital muscular dystrophy CMD: Congenital muscular dystrophy CMD refers to a group of muscular dystrophies that show them at or near birth. Muscular dystrophies in general are genetic, degenerative diseases primarily affecting voluntary muscles. The two forms that have been identified — Fukuyama and congenital muscular dystrophy with myosin deficiency which cause muscle weakness at birth or in the first few months of life, along with severe and early contractures shortening or shrinking of muscles that causes joint problems. Fukuyama congenital muscular dystrophy causes abnormalities in the brain and often seizures. Causes; Congenital muscular dystrophies progress slowly and affect males and females. CMD is caused by genetic mutations affecting some of the proteins necessary for muscles and sometimes for the eyes and or brain. Spinal curvature Learning disabilities or mental retardation Eye defects or seizures 7. Occulophayngeal muscular dystrophy OPMD Oculopharyngeal muscular dystrophy OPMD is a rare genetic muscle disorder with onset during adulthood most often between 40 and 60 years of age. OPMD is characterized by slowly progressive muscle disease myopathy affecting the muscles of the upper eyelids and the throat. It is an inherited genetic defect from either one or both the parents.
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